Context: 'Debbie Sengsavath  IT5180.'

% This program is designed to help students learn about
% genetic disorders but in an atmosphere where the student
% actually picks and chooses the phenotypes and genotypes
% to create, so to speak, a genetic disorder.

Dec 1 : 'Klinefelter Syndrome'
Dec 2 : 'Turner Syndrome'
Dec 3 : 'Cry of the Cat Sydrome'
Dec 4 : 'Albinism'
Dec 5 : 'Duchenne Muscular Dystrophy'
Dec 6 : 'Trisomy 13 (Patau Syndrome)'
Dec 7 : 'Tay Sachs Disease'
Dec 8 : 'Marfan Syndrome'
Dec 9 : 'Lesch-Nyhan Syndrome'
Dec 10 : 'PKU'
Dec 11 : "Trisomy 18 (Edward's Syndrome)"
Dec 12 : "Trisomy 21 (Down's Syndrome)"
Dec 13 : 'Cystic Fibrosis'
Dec 14 : 'Sickle Cell Anemia'

Dec 73.
Dec 74.
Dec 75.
Dec 76.
Dec 77.
Dec 78.
Dec 79.
Dec 82.
Dec 84.
Dec 85.
Dec 86.
Dec 87.
Dec 88.
Dec 89.

Question 1 :
'You have just been conceived with a genetic disorder and you will
determine your own fate by answering the following question -
What is the sex of the affected individual?'


       Why    'It is very important to know the most affected sex.'
   Answers  1 'Male'
            2 'Female'

Question 2 : 'How should the disorder be genetically distributed?'
       Why    'It is important to know who else is affected by the disorder.'
   Answers  1 'Males only'
            2 'More males than females'
            3 'More females than males'
            4 'Both males and females'

Rule 1 :
   IF Q1A1 and Q2A1 THEN D1

Rule 2 :
   IF Q1A1 and Q2A2 THEN D5          % this is a very severe disorder

Rule 3 :
   IF Q1A1 and Q2A3 THEN D73         % we need more information on this male

Rule 4 :
   IF Q1A1 and Q2A4 THEN D74         % we need more info. on this male

Question 3 : 'How should the disorder be genetically distributed?'
       Why    'Its important to know who else is affected by the disorder.'
   Answers  1 'Females only'
            2 'More females than males'
            3 'More males than females'
            4 'Both females and males'

Rule 5 :
   IF Q1A2 and Q3A1 THEN D2          % webbed neck is very dominant in this indiv.

Rule 6 :
   IF Q1A2 and Q3A2 THEN D82         % we need more info. on this female

Rule 7 :
   IF Q1A2 and Q3A3 THEN D5

Rule 8 :
   IF Q1A2 and Q3A4 THEN D84         % we need more info. on this female



Question 4 : 'Should the disorder be caused by a deletion of a chromosome arm?'
       Why    'The answer helps to narrow down the specific disorder.'
   Answers  1 'Yes'
            2 'No'

Rule 9 :
   IF (D73 or D82) and Q4A1 THEN D3  % indiv. cries like a cat when infant

Rule 10 :
   IF (D73 or D82) and Q4A2 THEN D6

Question 5 : 'Should the individual be void of pigmented skin?'
       Why    'Important to know if indiv. has melanin or no melanin.'
   Answers  1 'Yes'
            2 'No'

Rule 11 :
   IF (D74 or D84) and Q5A1 THEN D4  % Indiv. called albino-all white

Rule 12 :
   IF D74 and Q5A2 THEN D75          % We need more info. on this male

Rule 13 :
   IF D84 and Q5A2 THEN D85          % We need more info. on this female

Question 6 : 'Should the disorder be a lysosomal storage disorder?'
       Why    'Answering this helps to narrow down the disorder greatly.'
   Answers  1 'Yes'
            2 'No'

Rule 14 :
   IF (D75 or D85) and Q6A1 THEN D7

Rule 15 :
   IF D75 and Q6A2 THEN D76          % We need more info. on this male

Rule 16 :
   IF D85 and Q6A2 THEN D86          % We need more info. on this female

Question 7 : 'Should the individual display long bones and be very tall?'
       Why    'Important because some indiv. may have long arms but no disorder.'
   Answers  1 'Yes'
            2 'No'

Rule 17 :
   IF (D76 or D86) and Q7A1 THEN D8  % Abe Lincoln had this disorder

Rule 18 :
   IF D76 and Q7A2 THEN D77          % We need more info. on this male

Rule 19 :
   IF D86 and Q7A2 THEN D87          % We need more info. on this female

Question 8 : 'Should the individual exhibit a compulsive self destructive behavior?'
       Why    'Important to know if this indiv. eats everything-including skin.'
   Answers  1 'Yes'
            2 'No'

Rule 20 :
   IF (D77 or D87) and Q8A1 THEN D9  % Very severe disorder/needs physical restraints.'

Rule 21 :
   IF D77 and Q8A2 THEN D78          % We need more info. on this male

Rule 22 :
   IF D87 and Q8A2 THEN D88          % We need more info. on this female

Question 9 : 'Does the individual have enough of the enzyme phenylalanine hydroxylase?'
   Answers  1 'Yes'
            2 'No'

Rule 23 :
   IF D78 and Q9A1 THEN D79

Rule 24 :
   IF D88 and Q9A1 THEN D89

Rule 25 :
   IF (D78 or D88) and Q9A2 THEN D10

Question 10 : 'What other characteristic does this individual display?'
       Why    'It is important to know other phenotypic/genotypic traits of indiv.'
   Answers  1 'Rockerbottom feet & heart and kidney defects & mental retardation'
            2 'Mental retardation & abnormal facial features & low IQ'
            3 'Sweat gland dysfunction and respiratory problems'
            4 'Circulation problems and fatigue and swelling'

Rule 26 :
   IF (D79 or D89) and Q10A1 THEN D11

Rule 27 :
   IF (D79 or D89) and Q10A2 THEN D12

Rule 28 :
   IF (D79 or D89) and Q10A3 THEN D13

Rule 29 :
   IF (D79 or D89) and Q10A4 THEN D14