© 2000 Rainer Glaser.

The University of Missouri at Columbia
Chemistry 212 - Organic Chemistry II - Winter Semester 2000

COURSE SCHEDULE

Instructor Professor Rainer Glaser
Office 321 Chemistry Building
Telephone (573) 882-0331
E-Mail GlaserR@missouri.edu
Chemistry 212 Course Web Site http://www.missouri.edu/~chemrg/RG_T_WS00.html

There will be 59 lectures which includes an introduction and three one-hour-exams. We will dedicate 12 "lab" lectures to the discussion of laboratory chemistry and there will be 43 class periods for lectures and/or computer laboratory activities. Hence, we need to cover the material of 10 chapters in less than 40 lectures; that means, there are 3 - 4 hours allocated for each chapter. We need to move fast and you need to study from the start to keep up with this pace! The following course schedule is preliminary and I might lengthen or shorten parts of the course as needed. Suggested reading and exercises & self-study are specified in the last two columns. Self-study assignments will be added as the semester progresses. You should read the assigned chapters before the lecture. We will omit parts of various chapters and appropriate announcements will be made in class. And remember: Chemistry can be great fun but good things never come easy!

Nr. Day Date Topic Reading Self-Study & CSP
1 M 1/10 Introduction Syllabus et al. Review Course Web Site
2 W 1/12 Structure & MOs of Benzene Chapter 16.1-3 Form CSP Groups
3 R 1/13 Hueckel Rule and Examples Chapter 16.4-9 News Item 16
4 F 1/14 Fused (Hetero-)Aromatic Compounds Chapter 16.10-14 Problems Chapter 16
- M 1/17 Martin Luther King Recent History Submit Honors Contracts this week or next
5 W 1/19 Spectroscopic Properties of Aromatic Compounds Chapter 16.10-14 VC Chapter 16
6 R 1/20 Electrophilic Aromatic Substitution 1. Mechanism and Examples Chapter 17.1-2 Read
7 F 1/21 Electrophilic Aromatic Substitution 2.
Syntheses of Mono-Substituted Benzenes
Chapter 17.3-4, 17-10,11 Problems Chapter 17
8 M 1/24 Lab #1: Recrystallization Expt. #1 -
9 W 1/26 Electrophilic Aromatic Substitution 3.
Regiochemistry of Disubstitution
Chapter 17.7-9 News Item 17
10 R 1/27 Electrophilic Aromatic Substitution 4.
Trisubstitution, Tricks & Synthesis
Chapter 17 VC Chapter 17
11 F 1/28 Nucleophilic Arom. Subst. & Benzyne Mechanism, Side Chain Chemistry Chapter 17.12-15 CSP Groups Formed
Go surf the web!
12 M 1/31 Lab #2: Extraction Expt. #2 -
13 W 2/2 Aldehydes & Ketones 1.
Structure, Bonding, Nomenclature
Chapter 18.1-5 Problems Chapter 18
14 R 2/3 Aldehydes & Ketones 2.
Properties & Spectroscopy
Chapter 18.1-5 VC Chapter 18
15 F 2/4 Aldehyde & Ketones 3.
Syntheses
Chapter 18.7-11 Review!
Go surf the web!
16 M 2/7 Lab #3: SN Reactions Expt. #3 -
17 W 2/9 Aldehydes & Ketones 4.
Nucleophilic Additions
Chapter 18.12 &18.14-18 News Item 18
18 R 2/10 Examination #1 Chapter 16-18 -
19 F 2/11 Aldehydes & Ketones 5.
Wittig Reaction and Misc.
Chapter 18.13 & 18.19-21 Go surf the web!
20 M 2/14 Lab #4: Chromatography Expt. #4 -
21 W 2/16 Amines 1. Classification, Nomenclature, Structure & Physical Properties Chapter 19.1-8 & 19.12 Discuss Group Project Topic in Lecture
22 R 2/17 Amines 2. Spectroscopy and Syntheses Chapter 19.9-11 Problems Chapter 19
23 F 2/18 Amines 3: Syntheses Chapter 19.12-25 News Item 19
Go surf the web!
24 M 2/21 Lab #5: Electro. Aromat. Subst.
Amines 4. Reactions
Expt. #5 -
25 W 2/23 Amines 5. Reactions Chapter 19.12-25 VC Chapter 19
26 R 2/24 Carboxylic Acids 1. Nomenclature, Structure, and Physical Properties. Chapters 20.1-3 & 20.7 News Item 20
27 F 2/25 Carboxylic Acids 2: Spectroscopy, Acidity and Carboxylates. Chapter 20.4-5 & 20.6 & 20.8 Project Topic Approval
Go surf the web!
28 M 2/28 Lab #6: SBH Reduction
Carboxylic Acids 3. Sources and Syntheses.
Expt. #6, Ch. 20.9-10 & 20.12 Problems Chapter 20
29 W 3/1 Carboxylic Acids 4. Nucleophilic Acyl Substitution and Esterifaction. Chapter 20.11 & 20.13-15 VC Chapter 20
30 R 3/2 Carboxylic Acids 5. Chlorides, Amides, and Reductions Chapter 21 Exam #2 in 1 week! Plan ahead!
31 F 3/3 Carboxylic Acid Derivatives 1. Chapter 21 News Item 21
32 M 3/6 Lab #7: Identification of Unknown
Carboxylic Acid Derivatives 2.
Expt. #7
Problems Chapter 21
33 W 3/8 Carboxylic Acid Derivatives 3. Chapter 21 VC Chapter 21
34 R 3/9 Examination #2 Chapters 19-21 -
35 F 3/10 Carboxylic Acid Derivatives 4. Chapter 21 Big 12 Tournament
Go surf the Web!
36 M 3/13 Lab #8: Esterification Expt. #8 -
37 W 3/15 Enolates 1. Enolization, Halogenations of As, Ks & CAs, Alkylations of As & Ks Chapter 22.1-6 VC Chapter 22
38 R 3/16 Enolates 2. Aldol Condensation - Straight & Crossed, Inter & Intra. Chapter 22.7-11 Problems Chapter 22
39 F 3/17 Enolates 3. Chemistry of alpha,beta-unsaturated As & Ks Chapter 22 NCAA Go T.J.!!
40 M 3/20 Lab #9: Amide Synthesis Expt. #9 -
41 W 3/22 Enolates 4. Conjugate Additions & Michael Additions. Chapter 22.12-19 News Item 22
42 R 3/23 Enolates 5. Claisen Ester Condensation - Straight & Crossed, Inter & Intra. Chapter 22.12-19 -
43 F 3/24 Enolates 6. 1,3-Dicarbonyl Chemistry. Chapter 22.12-19 Submit CSP Project
- M 3/27 SPRING BREAK - -
- W 3/29 SPRING BREAK - -
- R 3/30 SPRING BREAK - -
- F 3/31 SPRING BREAK - -
44 M 4/3 Lab #10: Wittig Reaction Expt. #10 -
45 W 4/5 Enolates 7. 1,3-Dicarbonyl Chemistry. Alkylate & Decarboxylate. Chapter 22 -
46 R 4/6 No Class Today Chapter 15 VC Chapter 15
47 F 4/7 MOs (ethene, butadiene, allyl), Conjugation Chapter 15.2-4 & 15.7-9 News Item 15
48 M 4/10 Lab #11: Grignard Reaction Expt. #11 -
49 W 4/12 UV/Vis Spectroscopy 1 Chapter 15.13 Problems Chapter 15
50 R 4/13 UV/Vis Spectroscopy 2
& 1,2- and 1,4-Additions
Chapter 15.13
15.5-6 & 15.10
-
51 F 4/14 Diels-Alder 1: Basics & Stereochemistry Chapter 15.11-12 Submit Peer Review
52 M 4/17 Lab #12: Unknown Sugar Expt. #12 -
53 W 4/19 Diels-Alder 2: Regiochemistry and MOs Chapter 15.11-12 -
54 R 4/20 Examination #3 Chapter 15 & 22 -
55 F 4/21 Sugars 1: Classifications and Cyclic Structures of Monosaccharides Chapter 23.1-7 Organic Day on 4/22
56 M 4/24 Sugars 2: Reactions of Sugars Chapter 23.8-17 VC Chapter 23
57 W 4/26 Sugars 3: Di-, Oligo- & Polysaccharides Chapter 23.18-19 News Item 23
58 M 4/27 Nucleosides 1: Chapter 23 Problems Chapter 23
59 F 4/28 Nucleosides 2: Chapter 23 -
- M 5/1 FINALS WEEK - Review
- W 5/3 FINALS WEEK - Review
- R 5/4 FINALS WEEK - Review
60 F 5/5 Comprehensive Final, 3:30 - 5:30 pm Chapters 15 - 23 Review


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