1)      phentermine:





2)      The patient may have no symptoms at all.  However, a physician may notice a new heart murmur, or changes may be detected by an echocardiogram (a type of heart test).  If the disease is severe, the patient may experience shortness of breath, excessive tiredness, chest pain, fainting, and swelling of the legs (edema).

3)      Dexfenfluramine:




4)      Fenflurmine blocks serotonin uptake and provokes transport-mediated serotonin release, thus making the serotonin levels in the bloodstream higher which can lead to heart valve injury.