Kristin's Honors Project: Drug Label Analysis of Nasonex



Mometasone Furoate Monohydrate
CRS Registration Number 83919-23-7
Molecular Formula C27H30Cl2O6*H2O
Molecular Weight 539.45 g
Derivation Synthetic
Physical Description White powder
Melting Point NA
Boiling Point NA
Solubility Practically insoluble in water
Function Anti-inflammatory corticosteroid
- active ingredient
Density NA

Glycerin
CRS Registration Number 56-81-5
Molecular Formula C3H8O3
Molecular Weight 92.0944 g
Derivation Synthetic, animal, or vegetable origin
Physical Description Clear colorless viscous liquid
Melting Point 17.8 C
Boiling Point 290 C (dec)
Solubility Miscible
Function Storage buffer component
Density 1.261 g/mol

Microcrystalline Cellulose
CRS Registration Number 9004-34-6
Molecular Formula (C6H10O5)250
Molecular Weight 24,000 - 57,000 g (aprox)
Derivation Modified natural polymer
of derivated polysaccharides
Physical Description Colorless solid
Melting Point 260.05 - 270.05 C
Boiling Point (Dec)
Solubility Insoluble
Function Combination binder - disintegrant
Density 1.27g/mol
























Carboxymethylcellulose Sodium
CRS Registration Number 9004-32-4
Molecular Formula C6H7O2(OH)2OCH2COONa
Molecular Weight 160,000-560,000 g (aprox)
Derivation Cellulose fiber with sodium hydroxide
and chloroacetic acid
Physical Description White to off-white odorless
granulated powder
Melting Point >300.05 C
Boiling Point NA
Solubility Soluble in cold water
Function Emulsion stablizer and thickener
Density 0.75 g/mol

Sodium Citrate
CRS Registration Number 68-04-2
Molecular Formula C6H5Na3O7
Molecular Weight 258.07061 g
Derivation NA
Physical Description White powder
Melting Point 150C (becomes anhydrous)
Boiling Point NA
Solubility 760 g/L
Function Emulsifer aid
Density NA

Phenylethyl Alcohol
CRS Registration Number 60-12-8
Molecular Formula C8H10O
Molecular Weight 122.1664 g
Derivation NA
Physical Description Colorless liquid, floral odor
Melting Point -27C
Boiling Point 219 - 221 C
Solubility 20g/L(20 C)
Function Solvent in the manufacture of
pharmaceuticals, in organic synthesis
Density 1.023 g/mol






















Citric Acid
CRS Registration Number 77-92-9
Molecular Formula C6H8O7
Molecular Weight 192.125 g
Derivation Fermentation from dextrose
Physical Description Clear or white crystals
Melting Point 153 C
Boiling Point (Dec)
Solubility >=10 g/L (22 C)
Function pH control
Density 1.542 g/mol

Benzalkonium Chloride
CRS Registration Number 8001-54-5
Molecular Formula C9H13ClNR - general formula
to which R represents a mixture of alkyls
C8H17 to C18H37
Molecular Weight Varies
Derivation NA
Physical Description Yellow solid
Melting Point 29-34C
Boiling Point NA
Solubility 4000g/L(20 C)
Function Preservative/antimicrobial
Density 0.98 g/mol

Polysorbate 80
CRS Registration Number 9005-65-6
Molecular Formula C64H124O26
Molecular Weight 1308 g
Derivation Extracted from the Myrrh Gum Tree
Physical Description Yellow liquid
Melting Point NA
Boiling Point >100C
Solubility 5-10 g/L (23 C)
Function Emulsifer
Density 1.064g/mol




Key:
dec - decomposition
NA - not available















Here are some sites that helped me obtain some of the hard to find information
Analytics & Reagents (the MSDS pages)
Chemical Land21