CLARINEX - Drug Label Analysis
WS03 MU Chem 212 Honors Project




Desloratadine Dibasic Calcium Phosphate Dihydrate USP
Structure
Structure
Molecular Formula C19H19ClN2 Molecular Formula CaH5O6P
Molecular Weight 310.8 g Molecular Weight 172.09 g
Origin Synthetic. Origin Synthetic.
Physical Description White to off-white powder. Physical Description White to off-white powder.
Melting Point 260-270°C Melting Point ca. 100°C loses water.
Density 1.59 g/mol Density 2.39 g/mol
Solubility Very soluble in ethanol and propylene glycol. Somewhat soluble in water. Solubility Practically insoluble in water and alcohol. Insoluble in 3N hydrochloric acid and 2N nitric acid.


Microcrystalline Cellulose NF Corn Starch NF
Structure
Structure
Molecular Formula C12H22O11 Molecular Formula (C6H10O5)n where n=300-1000
Molecular Weight 342.30 g Molecular Weight 360.31 g
Origin Partially depolymerized alpha cellulose derived from purified specialty grades of wood pulp Origin Consists of the granules separated from the mature grain of corn.
Physical Description White, odorless, tasteless, relatively free-flowing powder. Physical Description Angular, white masses or a fine powder. Odorless and has a slight, characteristic taste.
Melting Point 494.11°C Melting Point Decomposes at 256-258°C
Bulk Density 0.28-0.33 g/cc Density 1.5 g/mol
Solubility Insoluble in water, in dilute acids, and in most organic solvents. Practically insoluble in sodium hydroxide solution. Solubility Insoluble in cold water and in alcohol.


White Wax NF Lactose Monohydrate
Structure
Structure
Molecular Formula N/A Molecular Formula C12H22O11·H2O
Molecular Weight N/A Molecular Weight 360.31 g
Origin Obtained from the bleached, purified wax from the honeycomb of Apis mellifera, the honey bee. Origin Obtained from milk, which consists of one glucose and one galactose moiety.
Physical Description A yellowish-white solid, somewhat translucent in thin layers, having a slightly rancid odor, and an insipid taste. Physical Description White or almost white, odorless powder.
Melting Point 65°C Melting Point 201°C
Density 6.75 lbs/gallon Density 1.52 g cm-3
Solubility Beeswax is soluble in ether, chloroform, carbon tetrachloride and vegetable oils. It is sparingly soluble in benzene and carbon disulfide when cold, and insoluble in water and mineral oil. Solubility Freely but slowly soluble in water (1 g in 4.63 mL) and practically insoluble in alcohol.


Hydroxypropyl Methylcellulose Carnauba Wax NF
Structure
Structure
Molecular Formula C56H108O30 Molecular Formula C61H122O2
Molecular Weight 1261.45 g Molecular Weight 887.62 g
Origin Derived from alkali treated cellulose that is reacted with methyl chloride and popylene oxide. Origin Obtained from the leaves of a palm tree known as Copernica cerifera, which is also referred to as the "Tree of Life".
Physical Description White or quasi-white fibrous powder, odourless and tasteless. Physical Description Yellow.
Melting Point N/A Melting Point 80-86°C
Density 3.90 g cm-3 Density 0.99 g/mol
Solubility Dissolves slowly in cold water. Insoluble in hot water. Soluble in most polar solvents. Insoluble in anhydrous alcohol, ether, and chloroform. Solubility It is soluble in chloroform, ether, and petroleum benzene when hot, but sparingly soluble when it is cold. It is sparingly soluble in hot ethanol and practically insoluble in water.


Polyethylene Glycol Titanium Dioxide
Structure
Structure
Molecular Formula C2H6O2 Molecular Formula O2Ti
Molecular Weight 62.07 g Molecular Weight 79.87 g
Origin Synthetic. Origin Titanium dioxide is manufactured by processing naturally occurring titanium- containing rutile or ilmenite minerals. Rutile is an impure form of titanium dioxide whereas ilmenite contains titanium combined with iron as a compound oxide.
Physical Description Clear, Physical Descriptionless, viscous liquid. Physical Description White, odorless powder.
Melting Point 65°C Melting Point 1855°C
Density 1.101 g/mol Density 4.26 g cm-3
Solubility Is water soluble, but the solubility is greatly reduced at temperatures approaching 0°C. Solubility Insoluble in water. <0.1 g/100 mL at 20°C



Created by Katie Hurrelmeyer as an Honors Project for Dr. Glaser's Winter 2003 Chemistry 212 class at the University of Missouri-Columbia.