Vitamin E May Be Harmful, Study Finds
November 10, 2004
NEW ORLEANS, Nov 10 (Reuters) - Vitamin E supplements,
which millions take in the hope of longer, healthier lives,
may do more harm than good, researchers reported on
In fact, people taking high doses of vitamin E may in some
cases be more likely to die earlier, although the reasons
are not clear, said Dr. Edgar Miller of Johns Hopkins
University in Baltimore, who led the study.
"I think people take vitamin E because they think it is
going to make you live longer, but this (study) doesn't
support that," Miller told reporters.
Miller and colleagues re-analyzed 19 studies of vitamin E
and health between 1993 and 2004. The trials involved more
than 136,000 mostly elderly patients in North America,
Europe and China.
People who took 200 international units of vitamin E a day
or more died at a higher rate during the study, which
lasted three years, than people who did not take
supplements, they told a meeting of the American Heart
"It's about a 5 percent increased risk at 45 years in the
trials pooled together," Miller said.
"That doesn't sound like a lot but if you apply it to 25
percent of the (U.S.) adult population taking vitamin E,
that is significant."
Miller, whose findings are also being published online by
the Annals of Internal Medicine, said two-thirds of people
who take vitamin E supplements take 400 IU or more.
"We don't think that people need to take vitamin E
supplements, that they get enough from the diet," he said.
Nuts, oils, whole grains and green leafy vegetables are all
rich in vitamin E.
MUCH MORE THAN NEEDED
The average U.S. diet supplies six to 10 IU of E, Miller
said. The Institute of Medicine, which sets recommended
doses of vitamins and minerals, gives 1,500 IU of E as a
daily upper limit.
"I would say it is too high," Miller said. The U.S.
government's Food and Drug Administration is barred by law
from regulating dietary supplements so the limits are
People take large doses of vitamin E in the belief
that it helps counter oxidation by unstable "free radical"
molecules, which damages cells and can accelerate aging and
lead to heart disease and cancer.
Miller, who was surprised by the findings of the study,
said there could be several ways the vitamin
supplementation is damaging the body.
While vitamin E in low doses is a powerful antioxidant, in
higher doses its effects may promote oxidative damage, and
may also overwhelm the body's natural antioxidants, he
Dr. Raymond Gibbons of the Mayo Clinic in Rochester,
Minnesota, said the evidence has been building against
vitamin E supplements.
"Despite this ... I see many, many patients still taking
vitamin E and I have to convince them not to," he told a
separate news conference.
But the Council for Responsible Nutrition, a trade group
for supplement makers, criticized the report.
"This is an unfortunate misdirection of science in an
attempt to make something out of nothing for the sake of
headlines," said the group's John Hathcock.