You are welcome to the new course we
offer for 2006 Winter semester
BE-4001; BE-7001; BE-8001
Topics in Biological Engineering
Nanobiotechnology
Elective
University Course Reference #: 19820,
19950
Class Time: 2006 Winter
Semester, Tues/Thurs 11:00-12:10, AE
125
Course Description:
Nanotechnology is an
interdisciplinary course that describes an emerging discipline dedicated to the
generation of products, devices for biotechnology and bioengineering
applications through integration of biology, chemistry, engineering and
state-of-art nanotechnology starting at the molecular level. Through dissecting
representative projects, the course will address latest advances broadly from
protein engineering, bio-mimic self-assembly, biomembrane engineering, to
various nano-tools for lab-on-a-chip and bio-silicon interface design. A
relevant topic throughout course will be: How molecules can be used as building
blocks to engineering surfaces and materials with specific attributes and
function. The course will
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Introduce the
uniquely designed molecular building blocks found in nature
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Discuss the driving
forces that lead to their spontaneous self-assembly
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Explain how
performance and function relate to the architecture of supramolecular assembly,
and
-
Introduce key
examples illustrating how one can borrow Nature’s design principles for
biomedical applications.
Course Objectives:
The goal of this course is to ignite students’ interests in this field by
exposing them to diverse amazing projects. Students will gain abilities to
integrate their multidisciplinary knowledge and skills into the
interdisciplinary research project designs. Students will be helped through the
course to seek future career interests. As
a long term goal of this course, the University will provide globally-oriented
and well-trained scientists and engineers the opportunity to become engaged in
continuing research and rise as future leaders in the field. This objective
fully satisfies the educational goal of MU.
Topics Covered:
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Genetic Engineering |
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PCR, Mutagenesis, Protein in vivo and in vitro
expression |
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Bio-conjugation |
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Protein/DNA modification, Bio/Silicon/Gold interface chemistry,
Molecular crosslink |
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Nano-observation and
nano-manipulation |
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Scanning Force
Microscope |
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Self-Assembled
Nanostructures and Applications |
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DNA Nanoribbon/grid/barcode, Bio-generation of nanoparticles,
Protein nanoarray, DNA-Protein assembled biosensors,
Nanocontainer for drug delivery and enzyme nanoreaction,
DNA-based parallel computing, Bioelectronics,
DNA-specific molecular lithograph |
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Biomotor and
nanomachine |
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Bioenergetics/Cell workhorse, Biomotor classification,
Nuclei acid enzyme and linear/rotary motor,
Technology for trapping single motor, Nanomachine with biomotor |
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Smart nanoparticles |
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Nanoparticle (NP) properties, NP-Imaging, NP-super sensors,
NP-Therapy,
NP-Bioelectronics |
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Lab-on-a-Chip |
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Soft-lithograph/micro-printing, Chip interface
modification/engineering,
Lipid membrane nanofluidic chip
Switchable electrical surface on chip surface |
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Single Molecule
Detection |
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Single molecule detection technology, Mathematics of stochastic
kinetics
Single molecule
enzymology, Ion channel based stochastic sensors
Biotic-abiotic
nanopores for high throughput screen |
Prequisites:
This course is primarily designed for senior undergraduate and graduate students
in biology, physics, chemistry, life science and engineering with interests in
pursuing projects on the bio-/nano-/eng- interface.
Textbooks:
Nanobiotechnology, Concepts, Applications and Perspectives, Eds, Niemeyer
C.M. and Mirkin C.A., Wiley-VCH, ISBN: 3-527-30658-7
Grading:
Mid-term
exam-Presentation 25%
Final exam-Project design
35%
Laboratory experiment
10%
Homeworks by sections 20%
Class participation
10%
Graduate Credit:
Graduate students enrolled for graduate credit will be required to do an
additional project.
Class/Laboratory schedule:
3 credit lectures/wk, 75 minutes/lecture, 3 credit hours for laboratory per
semester.
Related program outcomes:
Students will attain two major outcomes that can be assessed by measurable
performance criteria, (j) knowledge of contemporary issues and
(l) ability to integrate engineering and biological sciences to develop systems
and processes for improved health, bio-resource utilization, and environmental
protection.