Peer-reviewed publications

Yang X, Sheng W, He Y, Cui J, Haidekker MA, Sun GY, Lee JCM. Secretory phospholipase A2 type III enhances a-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity. Journal of Lipid Research 2009; (Accepted)

Sheng Y, Wang G, Chen L, Li H, Yu P, Bai M, Zhang Q, Lee JCM, Yu Q. Investigation of surface endothelialization on biomedical nitinol (NiTi) alloy: Effects of surface micropatterning combined with plasma nanocoatings. Acta Biomaterialia 2009; (Accepted)

Zhu D, Hu C, Sheng W, Tan KS, Haidekker MA, Sun AY, Sun GY, Lee JCM. NADPH oxidase-mediated reactive oxygen species alter astrocyte membrane molecular order via phospholipase A2. Biochemical Journal 2009; 421(2): 201-10. PDF

Wang Y, Wang G, Chen L, Li H, Yin T, Wang B, Lee JCM, Yu Q. Electrospun nanofiber meshes with tailored archectures and patterns as potential tissue-engineering scaffolds. Biofabrication 2009; 1 (1): 1015001. PDF

Hicks JB, Lai Y,Sheng W, Yang X, Zhu D, Sun GY, Lee JCM. Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2. Biochimica et Biophysica Acta-Biomembrane 2008; 1778: 2512-2519. PDF

Shelat PB, Chalimoniuk M, Wang J, Strosznajder J, Lee JCM, Sun AY, Simonyi A, Sun GY. Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. Journal of Neurochemistry 2008 ; 106 (1): 45 - 55. PDF

Nipper ME, Majd S, Mayer M, Lee JCM, Theodorakis EA, Haidekker MA. Characterization of changes in the viscosity of lipid membranes with the molecular rotor FCVJ. Biochimica et Biophysica Acta-Biomembrane 2008; 1778(4):1148-1153. PDF

Zhu D, Haidekker MA, Lee JS, Won YY, Lee JCM. Application of molecular rotors to the determination of the molecular weight dependence of viscosity in polymer melts. Macromolecules 2007; 40: 7730-7732. PDF

Zhu D, Lai Y, Shelat PB, Hu C, Sun GY, Lee JCM. Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction. Journal of Neuroscience 2006; 26(43): 11111-11119. PDF

Zhu D, Tan KS, Zhang X, Sun AY, Sun GY, Lee JCM. Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes. Journal of Cell Science 2005; 118 (16): 3695-3703. PDF

Lee JCM, Gimm JA, Lo AJ, Koury MJ, Krauss SW, Mohandas N and Chasis JA. Mechanism of protein sorting during erythroblast enucleation: role of cytoskeletal connectivity. Blood 2004; 103: 1912-1919. PDF

Lee JCM, Santore M, Bates FS and Discher DE. From membranes to melts, rouse to entangled: diffusion in polymersome versus lipid bilayers. Macromolecules 2002; 35: 323-326. PDF

Lee JCM and Discher DE. Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfolding. Biophysical Journal 2001; 81: 3178-3192. PDF

Lee JCM, Law R, and Discher DE. Bending contributions to the hydration of phospholipid and block copolymer membranes – unifying correlations between probe fluorescence and vesicle thermoelasticity . Langmuir 2001; 17: 3592-3597. PDF

Lee JCM, Bermudez H, Discher BM, Sheehan MA, Won Y-Y, Bates FS and Discher DE. Preparation, stability, and in vitro performance of vesicles made with diblock copolymers. Biotechnology and Bioengineering 2001; 73: 135-145. PDF

Lee JCM, Wong D and Discher DE. Direct measures of large, anisotropic strains in deformation of the erythrocyte cytoskeleton. Biophysical Journal 1999; 77: 853 – 864. PDF

Discher BM, Won Y-Y, Ege DS, Lee JCM, Bates FS, Discher DE and Hammer DA. Polymersomes: Tough vesicles made from diblock copolymers. Science 1999; 284: 1143 – 1146. PDF

Patent Filing

Polymersomes and Related Encapsulating Membranes.

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