August 15-20, 2004

Gordon Research Conference on Macromolecular Organization and Cell Function

Queen's College, Oxford, U.K.

Sponsors:

 

Merck & Co., Inc. - USA

 

The Company of Biologists Ltd.

 

Novartis Institutes for BioMedical Research, Inc.

 

Sanofi-Chinoin Pharmaceuticals Ltd

 

Laurin Publishing (Photonics Spectra)

 

New England Biolabs

 

Trends In Biochemical Sciences (Sponsor of the Paul Srere Memorial Lecture), Elsevier Publishers

 

Cambridge Isotope Laboratories

 

National Science Foundation

 

National Institutes of Health (NIGMS and NIDDK)

 

Cell Press (Molecular Cell)

 

 

Links:


How to apply


GRC Home Page


Exchange Rates


Oxford links


Meeting site

 

Take a Virtual Tour of Queen's College (Quick Time required)


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Chairs:

Christopher Hardin, University of Missouri, Columbia, MO, USA (lab web site)

Judit Ovadi, Hungarian Academy of Sciences, Budapest, Hungary (lab web site)

Vice-chairs:

Ron Lynch,  University of Arizona, Tucson (lab web site)

Steve Oliver, University of Manchester, UK (lab web site)

Program:

"FINAL PROGRAM":

SUNDAY AFTERNOON :

PRE-MEETING TRAINEE SYMPOSIUM- informal and unofficial

SUNDAY EVE (7:30-9:30):

Conference Welcome:  Christopher Hardin

Session 1) Cell Interior and Microdomains (Session Leader Jim Clegg, UC Davis, Bodega Bay)   

  • Guy A Rutter: Dynamic imaging of free ATP and calcium microdomains in single cells: consequences for stimulated insulin secretion. University of Bristol, UK

  • Alasdair C. Steven: Prionogenesis in yeast: structural transition and functional repercussion. NIH
  • Alice Y. Ting:  Post-translational modification reporters and site-specific protein labeling in cells.   MIT.  

MONDAY MORNING (9:00-12:30):

Session 2) Physico-chemistry of Macromolecular Assemblies (Session Leader, Jan Hoh)

  • Jan H. Hoh: AFM measurements of forces that organize neuronal cytoskeleton. Johns Hopkins University  
  • Georg Schulz:  Designed self-assembly of proteins.  Freiburg im Breisgau, Germany.
  • Bertrand Seraphin: Analyzing protein complexes.  CNRS France
  • Harvey T. McMahon: Membrane bending and curvature sensing.  Cambridge

MONDAY AFTERNOON (16:00-17:45):

Poster Flashes (3 minute mini talks (1 minute questions) to introduce poster presentations).  Moderated by Ron Lynch and Steve Oliver

MONDAY EVE (19:30-21:30):

Session 3) Organization of Gene Expression (Session Leader: Murray Deutscher, University of Miami)  

  • Chris Mathews: Protein-protein Interactions in DNA Precursor Biosynthesis.  Oregon State University  

  • Magda Konarska: The spliceosome -- mechanism of substrate selection and connections to transcription.  Rockefeller University

  • John McCarthy: Control of assembly steps in the eukaryotic translation initiation pathway.  University of Manchester, UK

TUESDAY MORNING (9:00-12:30):

Session 4) Micro- Domains for Organization of Cell Functions (Session Leader: Ron Lynch, University of Arizona)

  • Richard Paul: Compartmentation of Na-K ATPase a-isoforms, Glycolysis And Contractile Function In Vascular Smooth Muscle: Evidence from Transgenic Mice.  Univ. of Cincinnati

  • Paul Insel: Caveolar Microdomains in G protein-coupled receptor signaling.   UC- San Diego  

  • Dermot Cooper: Cellular strategies for co-localizing Calcium-sensitive adenylyl cyclases and Calcium-entry pathways.  University of Cambridge, UK

  • Robert Balaban:  Metabolic control network of the mitochondrion: Application of new discovery tools.  NIH.

TUESDAY AFTERNOON (16:00-17:45):

Poster presentations

TUESDAY EVE (19:30-21:30):

Session 5)  Metabolomics (Metabolic Networks ): Theory and Experiments (Session Leader: Doug Kell)

  • Wolfram Weckwerth: Metabolic networks and their structural characteristics at a plant-systems level.  Max Planck Institute
  • Julie Dickerson: Creating and modeling metabolic and regulatory networks using text mining and fuzzy expert systems.   Iowa State University.  
  • Vladimir Shulaev: Metabolomics for yeast systems biology.  Virginia Tech.

WEDNESDAY MORNING (9:00-12:30):

Session 6)  Protein Assemblies with the Cytoskeleton (Session Leader: Judit Ovadi)

  • Jürgen Bereiter-Hahn: Functional organization of glycolytic enzymes as related to locomotion and apoptosis.  Goethe University , Frankfurt
  • Kun Ping Lu: Novel cytoskeleton regulatory mechanism and its role in Alzheimer's disease.  Harvard University
  • Poul H. Jensen: Upstream and down stream of alpha-synuclein aggregation. Aarhus University, Denmark 
  • Soren Andersen: The microtubule connection: to Zebrafish spinal neurons from Xenopus mitotic spindles.

WEDNESDAY AFTERNOON (16:00-17:45):

Poster presentations

WEDNESDAY EVE (19:30-21:30):

Session 7)  Measurement and Modulation of Protein-Protein Interactions  (Session Leader: Steve Oliver)

  • Balazs Papp: Dosage sensitivity of protein complex subunits and genome evolution.    Budapest
  • Andrea G. Cochran: Peptide-Based Strategies for Targeting Protein-Protein Interactions, Genentech  
  • Michael Snyder: Global Analysis of Protein Activities Using Protein Chips.  Yale University

THURSDAY MORNING (9:00-12:30):

 Session 8)  Enzyme Localization in the Control of Metabolism (Session Leader: Tim Moerland)

  • Ronald Meyer: A critical analysis of the creatine shuttle.  Michigan State University  
  • Valdur Saks: Functional coupling as a basic mechanism of regulation in multienzyme complexes and energy transfer networks.  Universite Joseph Fourier, Grenoble, France
  • Lonny Levin: Insulin secretion via metabolic activation of soluble adenylyl cyclase
  • Loranne Agius: Compartmentation of glucokinase in the liver and pancreatic beta-cell.  Newcastle upon Tyne.  

THURSDAY AFTERNOON (16:30-17:30):

Poster presentations  

THURSDAY EVE (18:00-19:30 Banquet, 19:30-21:30 session)

Conference Banquet and Awards

Session 9)  The Paul Srere Memorial Lecture:

  • Introduction (Christopher Hardin)

  • Hans V. Westerhoff:  Integrative Systems Biology: Law and Order out of Chaos?  BioCentrum Amsterdam